Dr. Etminan published a case-control study on the risk of upper gastrointestinal bleeding with oral bisphosphonates.
Abstract Background: Gastrointestinal injuries including gastric ulcers have been reported with oral bisphosphonate therapy. However, the risk of the more serious upper gastrointestinal bleeding (UGB) especially in the community setting with these drugs is unknown. Similarly, the risk of UGB among users of both bisphosphonates and non steroidal anti-inflammatory drugs (NSAIDs) is the community is also unknown. We conducted a pharmacoepidemiologic study to explore these two questions.